Protein Expression is the method of generating some quantity of a specific protein in biotechnology. It refers to how proteins are synthesized, modified, and regulated in living organisms. Proteins are synthesized and regulated depending upon the functional need in the cell. The blueprints for proteins are stored in DNA and decoded by highly regulated transcriptional processes to produce messenger RNA (mRNA). The message coded by an mRNA is then translated into a protein. Transcription is the transfer of information from DNA to mRNA, and translation is the synthesis of protein-based on a sequence specified by mRNA. Protein expression systems are used in the life sciences, biotechnology, industrial fermentation, medicine &biopharmaceuticals production such as human insulin to treat diabetes and manufacture enzymes. Molecular biology research uses numerous proteins and enzymes, many of which are from expression systems, particularly DNA polymerase for PCR, reverse transcriptase for RNA analysis, restriction endonucleases for cloning, and to make proteins that are screened in drug discovery as biological targets or as potential drugs themselves.
The global protein expression market size was valued at USD 2,321 million in 2019 and projected to reach USD 4,728 million by 2027, growing at a CAGR of 11.2% during the forecast period, 2020-2027. The major factors are the growing demand for protein therapeutics and disease diagnostic. Additionally, the increasing R&D investments and rising research activities in the life science sector will spur the global protein expression industry in the future periods. Furthermore, the growing public-private funding for protein production activities and rigid government regulations to develop biologics is expected to witness remarkable growth of protein expression. The increasing cases of chronic conditions, including cancer, diabetes, arthritis, infectious diseases, and rising needs of drug design & development are expected to propel the demand for protein expression over the coming years. Moreover, the upsurge in demand for protein expression for the manufacturing and development of biologics such as vaccines, therapeutics, insulin, hormones, antibodies, and other products fuel the demand for protein expression in the healthcare market. Additionally, Protein expression technology and the system is extensively used in pharmaceutical, biopharmaceutical and biotechnology industry for the production of medication including vaccines, human growth hormone, insulin, interferons, target-specific drug, will bolster the growth of global protein expression market.
Protein expression technology is used to manufacture medication and drugs, effectively treating chronic diseases and analyzing biological activities. Protein expression technology allows high throughput screening of different reaction conditions, genes, and supplements cost-effectively are extremely important for future drug development. Technological advancements in Protein expression have changed the previous trend, making the yield much higher and cost much lower, thus allowing the production of such protein-based therapeutics on an industrial scale and opening the door for the treatment of multiple diseases and disorders.
Based on the types of systems, the global protein expression market is segregated into cell-free expression systems, algal-based expression systems, insect cell expression systems, prokaryotic expression systems, mammalian cell expression systems, and yeast expression systems. The mammalian cell expression system segment is estimated to witness the highest growth over the analysis timeframe due to its use in producing antibodies and therapeutics proteins. This system provides an advantage to pharmaceutical & biopharmaceutical companies for the manufacturing of biologics. Also, the mammalian cells can properly and efficiently recognize the signals for synthesis, processing, and secretion of eukaryotic proteins.
The insect cell expression systems will grow significantly due to large capacity, high expression efficiency, and rising government support for research activities. The availability of advanced systems such as baculo virus expression systems for protein-protein interaction studies is also driving the market’s growth.
The global protein expression market is categorized into Instrument, reagents, expression vectors, competent cells, and services based on the product. The reagent segment is held for a significant market share in 2019 and will gain maximum market revenue by 2027. It is attributable to the widespread application in biopharmaceutical, therapeutics, and industrial research. The service segment is poised to witness significant growth over the forecast period. It is due to increasing R&D activities and the large-scale production of vaccines and antibodies.
The global protein expression market is classified into therapeutics, industrial, and research & diagnostics applications based on the application. Therapeutics is expected to be the highest revenue share for protein expression during the forecast period. The segment’s growth is primarily attributed to highly efficient biologics with effective replacement treatment without gene therapy.
The research and diagnostics application will witness a lucrative growth rate in the estimated period due to the prevention of chronic diseases such as cancer, diabetes, and other infectious diseases and also rising government funding for proteomics& genomics research.
Based on the end-user, the global protein expression market is segmented into pharmaceuticals and biotechnology companies, academic institutions, CROs, etc. The pharmaceutical & biotechnology companies segment will dominate the global protein expression market by 2027 due to the surge in demand for drug development, insulins, growth hormones, and therapeutics.
The contract research organizations accounted for the largest share of the protein expression market in 2019 because of the rising outsourcing activities for developing new drugs and biologics.
The global protein expression market is separated into North America, Asia Pacific, Europe, South America, and Middle East & Africa. North America is estimated to project considerable patients over 2020-2026. It is owing to advents in technology, the presence of leading industry players offering innovative products, and increasing life science research.
The Asia Pacific will capture a prominent share of the protein expression market by 2027. Due to the increasing cases of chronic conditions with rising demand for protein therapeutics, continually improving healthcare infrastructure in the region, and rising demands for biologics in emerging countries such as India and China.
Companies such as Agilent Technologies Inc, Bio-Rad Laboratories Inc, GenScript, Takara Bio Inc, New England Biolabs, Promega Corporation, Oxford Expression Technologies Ltd, Merck KGaA, QIAGEN, and Thermo Fisher Scientific In a care the key players in the global protein expression market.