Oligonucleotide synthesis is the chemical process of relatively short fragments of nucleic acids with a defined chemical structure. It offers rapid and inexpensive access to custom-made Oligonucleotides of desired sequences and extremely useful in current lab practices. It has several applications in life science research, molecular biology, and medicine. It is used as anti-sense oligonucleotides, primers for DNA sequencing & amplification, synthesis of artificial genes, small interfering RNA, probes for detecting complementary DNA or RNA via molecular hybridization, and tool for the targeted introduction of genetic mutation.
The global oligonucleotide synthesis market is projected to gain a spurring CAGR in the forecasting period 2020-2027. The major factors are the growing demand for oligo-based drugs and increasing R&D investments. Additionally, the increasing research activities in the pharmaceutical & biotechnology sector and rising demand for new diagnostic methods & siRNA or anti-sense therapeutic will spur the global oligonucleotide synthesis industry in the future periods. Furthermore, the growing public-private funding for oligonucleotides synthesis activities and the easy development of customized medical products is expected to witness remarkable growth of Oligonucleotides synthesis. The increasing usage of oligonucleotides synthesis in diagnostics and industrial and academic from initial research and screening through target validation and drug production are expected to propel the demand for oligonucleotides synthesis over the coming years.
Moreover, the upsurge in demand for oligonucleotide synthesis for drug discovery to target various conditions such as cardiovascular diseases, ocular disorders, and cancer positively impacts the market for the oligonucleotides synthesis industry. Furthermore, the rapid expansion in customer base, rise in the extensive R&D activities at the industrial level, and increasing scope of genetic research are fueling the demand for the oligonucleotides synthesis market. The most common use of synthetic oligonucleotides as primers and probes for applications such as to lead enzymatic reactions, gene expression, cloning, DNA sequencing, and molecular diagnostics will bolster the growth of global oligonucleotide synthesis market share. Additionally, the growing geriatric population and increasing healthcare scope in the developing world swelling the growth of the oligonucleotides synthesis market across the globe.
Earlier, an automated method of oligonucleotides synthesis was carried out manually in solution or on solid phase supports using glass columns. However, due to rising development in technique, oligonucleotides synthesis is carried out automatically on solid-phase supports by using a computer control system. The oligonucleotide synthesizers are highly available commercially for small-scale synthesis and medium to large scale synthesis. With the increasing demand for oligo-based research, companies focus on technology improvisations for high throughput synthesis with cost control to get more attention from the end-users and gain maximum revenue.
The global oligonucleotide synthesis market is segregated into equipment, reagents & consumables, and services based on the product. The service segment is estimated to the highest growth over the analysis timeframe due to the rising in contract manufacturing services with coupled benefits such as cost-effectiveness, fast product development, and improved production efficiency. The Reagents & Consumables will grow significantly due to the rising oligonucleotide synthesis systems adoption and utilization of a wide range of reagents for purification, labeling, and modification of oligonucleotides.
Based on the type, the global oligonucleotide market is categorized into custom oligonucleotides and pre-designed oligonucleotides. The pre-designed oligonucleotides are further segmented into primers, probes, and linkers & adaptors. Furthermore, the custom oligonucleotide is divided into large-scale oligonucleotide synthesis, intermediate-scale oligonucleotide synthesis, and small-scale oligonucleotide synthesis. The primers segment held for a significant market share in 2019 and will gain maximum market revenue by 2027. It is attributable to the widespread application of PCR primers across the research and diagnostic fields due to the low cost and high sensitivity.
The large-scale oligonucleotide synthesis segment is poised to witness significant growth over the forecast period as it is the constantly evolving process for chromatographic purification of the crude oligonucleotide.
The global oligonucleotides synthesis market is classified into research, diagnostic, and therapeutic applications based on the application. The research applications are expected to be the highest revenue share for oligonucleotide synthesis during the forecast period. The segment’s growth is primarily assigned to the user in various research techniques, including PCR, qPCR, Gene Synthesis, Sequencing, increasing demand for oligo-based drugs, and rising advancement in next-generation sequencing technology.
The diagnostic applications will witness a lucrative growth rate in the estimated period due to advances in detection technology and the rising demand for disease diagnosis.
Based on the end-user, the global oligonucleotides synthesis market is segmented into hospitals, diagnostic laboratories, pharmaceuticals and biotechnology companies, and academic & research institutes. The hospital segment will dominate the global oligonucleotides synthesis market by 2027 due to the surge in the number of hospitals & clinics using oligonucleotide drugs for disease treatment, and the government center on vast healthcare policies.
The pharmaceuticals and biotechnology companies assigned for the largest share of the Oligonucleotide synthesis market in 2019 because of the increasing use of oligonucleotides synthesis in drug discovery and rapid adaptation of PCR products & progress in genomic studies.
By geography, the global oligonucleotides synthesis market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa.
North America is estimated to project considerable growth over 2020-2026. It is owing to advents in technology, the presence of leading industry players offering innovative products, and increasing healthcare expenditure.
The Asia Pacific will capture a fair share of the Oligonucleotide synthesis market by 2027. Due to the increasing adoption of advanced research technologies, we are continually improving/enhancing healthcare infrastructure in the region and mounting health care expenditures in developing countries such as India and China.
Companies such as Thermo Fisher Scientific Inc., Agilent Technologies, GE Healthcare, Biogen International, Bio Automation Corporation, Inc, Bio-Synthesis Inc, ATD Bio Ltd, LGC Biosearch Technologies, Sarepta Therapeutics, Gene Design Inc., TriLink Bio Technologies, Sarepta Therapeutics, Gen Script Inc, and Sigma-Aldrich Corporation are the key players in the global oligonucleotide synthesis market.