Global Hydrophobic Interaction Chromatography Market Overview:
The global hydrophobic interaction chromatography market is estimated to reach USD 1143 million by 2030, with growth at a CAGR of 5.4% in the forecast period from 2022-2030, and it was valued at USD 689 million in 2022.
Hydrophobic Interaction Chromatography is a strong analytical technique used to separate proteins from one another. It involves hydrophobic groups such as phenyl, octyl, or butyl attached to the stationary column. HIC is a liquid chromatography used to purify and separate biomolecules by their hydrophobic interactions. HIC is a preferred technology for the separation of Protein compared to the other protein separation chromatography as it employs a less denaturing environment, maintains high biological activity, and less structural damage than others. HIC offers superior selectivity for removing aggregated species and undesirable misfolded or variant forms of a protein.
Global Hydrophobic Interaction Chromatography Market Insights
The significant factors are the growing demand for monoclonal antibodies for the disease diagnosis and treatment of infectious diseases such as cancer. Additionally, the increasing utilization of hydrophobic interaction chromatography in the pharmaceuticals and biotechnology, food, and cosmetics industries to purify Protein and other biomolecules will spur the global hydrophobic interaction chromatography industry in the future periods. Furthermore, the growing public-private funding for protein purification techniques and increasing R&D investments are expected to witness remarkable growth of hydrophobic interaction chromatography. The expanding usage of hydrophobic interaction chromatography for purification of monoclonal antibodies for in-vitro diagnostics use and clinical studies of passive immunotherapy of HIV is expected to propel the demand for hydrophobic interaction chromatography over the coming years.
Moreover, the upsurge in demand for hydrophobic interaction chromatography to study drug-protein interaction and the rising demand for drug discovery& protein therapeutics positively impact the market for the hydrophobic interaction chromatography industry. Furthermore, the rapidly expanding customer demand base, rise in the extensive R&D activities at the academic and industrial level, and increasing range of biomedical applications are making the demand for hydrophobic interaction chromatography in the healthcare market. The growing usage of hydrophobic interaction chromatography in the removal of product-related impurities and contamination will bolster the growth of global hydrophobic interaction chromatography market share. Additionally, the ever-increasing geriatric population and growing healthcare demands in the developing world propelling the development of the hydrophobic interaction chromatography market across the globe.
Growth Driver
Hydrophobic interaction chromatography (HIC) is widely used in isolating protein complexes and studying protein folding and unfolding. HIC has several advantages when coupled with ion-exchange chromatography, such as purification of recombinant HIV reverse transcriptase and mammalian transcription factor. HIC is also widely used in research laboratories. Because of the advantages of large market size, low market concentration, and gradual maturity of technology applications, HIC technology has attracted various enterprises to the layout. HIC technology has some benefits, such as loading large sample volumes and samples eluted with low salt. It reduces ionic strength will create high revenue in the healthcare industry. However, restrictions are often challenging to achieve. Also, the lack of trained professionals& qualified researchers and increasing use of alternative chromatography such as ion exchange and affinity chromatography may hamper the growth of the HIC market. Moreover, a hydrophobic interaction chromatography resin effectively used in separation techniques in the pharmaceuticals industry, food and beverages industry, water and environmental analysis, and diagnostics.
Product and Services Segmental Analysis
The global hydrophobic interaction chromatography market is segregated into resins, columns, buffers, other products, and services based on the product and services. The HIC resins segment is estimated to witness the highest growth over the analysis timeframe due to the rising demand for HIC resins to purify Protein, polypeptide, enzyme, and nucleic acid and increase use in water and environment analysis.
The column segment will grow significantly during the forecast period due to increased detection sensitivity, high efficiency & flow rate, and faster separation speed.
Sample Segmental Analysis
The global hydrophobic interaction chromatography market is categorized into monoclonal antibodies, vaccines, and other samples based on the model. The monoclonal antibodies segment held for a significant market share in 2021 and will gain maximum market revenue by 2030. It is attributable to the rising demand for cancer diagnosis and treatment and increasing applications in autoimmune disorders and infectious diseases.
The vaccines segment is poised to witness significant growth over the forecast period due to rising demand for maximum purity in vaccines downstream processing and the increasing need to prevent and treat cancer and infectious disorders.
End-User Segmental Analysis
Based on the end-user, the global hydrophobic interaction chromatography market is segmented into pharmaceutical & biopharmaceutical companies, research & academic institutes, and CROs & CMOS. The pharmaceuticals and biotechnology companies segment will dominate the global hydrophobic interaction chromatography market by 2030. Due to the rising research and development funding by biopharmaceutical companies, increasing demand for therapeutic antibodies, and increasing use of HIC in the clinical trial setting.
The CROs and CMOs accounted for the largest share of the hydrophobic interaction chromatography market in 2021 on account of the increasing demand for purification of Protein and other biomolecules and rising research in the field proteomics.
Region Segmental Analysis
By geography, the global hydrophobic interaction chromatography market is segmented into North America, Europe, Asia Pacific, South America, and Middle East & Africa. North America is estimated to projected considerable growth over 2022-2030. Due to the high demand for protein biologics, the adoption of automated purification technology, the presence of leading industry players offering innovative products, and increasing healthcare expenditure.
The Asia Pacific will capture a significant share of the hydrophobic interaction chromatography market by 2030. Due to the advents in technology, we are continually improving health care infrastructure in the region and mounting health care expenditures in developing countries such as India and China.
Competitor Analysis
Companies such as Thermo Fisher Scientific, Waters Corporation, Sartorius AG, GE Healthcare, Bio-Rad Laboratories, Geno Technology, Tosoh Corporation, and Sepax Technologies are the key players in the global hydrophobic interaction chromatography market.
Key Stakeholders
- Market research and consulting firms
- Industry associations
- Global hydrophobic interaction chromatography manufacturing firm
- Research organizations and consulting companies
- Organizations, associations, and alliances related to hydrophobic interaction chromatography
- Regulatory bodies
- Suppliers
- Retailers
Recent Developments
- In August 2022, Sunresin introduced its most recent SEPLIFE products and solutions, including microcarriers for cell culture and chromatography resins for downstream purification, at the 2nd China International Vaccine Innovation Summit.
- In October 2022, VDO Biotech marked the Annual European Society of Gene & Cell Therapy in Edinburgh, England. VDO Biotech is a bioprocessing technology company that can show affinity chromatography media for viral and plasmid purification.
The objective of the research
- Market modeling starts with identifying a target market where historical data exists. A Market can include prediction problems, economic factors, analyzing customer behavior, and identifying new patterns from past events, which helps our client deep dive into the market.
- Product analysis involves examining product features, costs, availability, quality, and other aspects. Product analysis is conducted to understand potential buyers and to ensure competition in the market.
- Market Trend and Economic Factors Analysis helps assess potential changes to an economy’s inflation rate, taxes, interest rates, exchange rates, trading regulations, and excise duties that can significantly affect the target market.
- Market Segmental Analysis defines an in-depth scenario of the target market by grouping consumers into naturally existing created segments of consumers, share similar product preferences or characteristics.
- The geographical mapping approach helps our clients to understand national or international markets because different consumers in different regions have different needs, wants, and cultural characteristics that they can specifically target.
Market Modelling
By Product and Services
- Resins
- Columns
- Buffers
- Other Products
- Services
By Sample
- Monoclonal Antibodies
- Vaccines
- Other Samples
By End-User
- Pharmaceuticals and Biotechnology Companies
- Research & Academic Institutes
- CROs & CMOS
By Region
- North America
- Europe
- Asia Pacific
- South America
- Middle East & Africa
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